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DNA, Chromosomes & Genes
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GENOME

  • The nucleus of a human cell contains between 30 000 and 40 000 genes. This complete set of genes is called the GENOME.
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Describe the structure of the genome
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Describe the structure of the genome
  • Tightly coiled threads of deoxyribonucleic acid (DNA) and associated protein molecules
  • Organized into structures called chromosomes
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What are CHROMOSOMES?
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What are CHROMOSOMES?
  • A packet of coiled up DNA
  • Humans have 23 pairs of chromosomes
  • They are in the nucleus of cells
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What are CHROMOSOMES?
  • Chromosomes contain a single, long piece of DNA
  • A chromosome is about 0.004 mm long
  • The DNA is about 4 cm long
  • This is about 10 000 times longer than the chromosome
    • So it has to twist and coil to fit inside

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What are CHROMOSOMES?
  • There are 23 pairs of chromosomes in the nucleus of any one of your cells
  • Each chromosome has a single strand of DNA (deoxyribonucleic acid) which carries the code for a couple of thousand genes
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What is a GENE?
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What is a GENE?
  • A code made up of pairs of bases carried on the DNA molecule.
  • Each DNA molecule contains many genes
  • The basic physical and functional units of heredity


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What is a GENE?
  • A specific sequence of bases
    • Sequences carry the information needed for constructing proteins
      • Proteins provide the structural components of cells and tissues as well as enzymes for essential biochemical reactions.
  • The human genome is estimated to be made of more than 30,000 genes.
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What is a GENE?

  • Each chromosome carries a couple of thousand genes
  • Many of these are common to all human beings.
  • So, 99.9% of your DNA is identical to everyone else's


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What is a GENE?
  • The remaining 0.1% influences the differences between us
    • height, hair color and susceptibility to a particular disease
  • Environmental factors, such as lifestyle (for example, smoking and nutrition) also influence the way we look and our susceptibility to disease


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What is DNA?
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What is DNA?
  • The DNA molecule is made from two strands, twisted together in a double helix.
  • The links between each strand are called bases.
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What is DNA?
  • Deoxyribonucleic acid
  • The molecule that contains the genetic code
  • It coils up tightly inside chromosomes
  •  DNA is a double helix made from two strands which are joined together by a pair of bases
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What is DNA?
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What is DNA?
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Describe the DNA molecule
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Describe the DNA molecule
  • Two strands that wrap around each other to resemble a twisted ladder whose sides
  • Made of sugar and phosphate molecules
  • Connected by rungs of nitrogen- containing chemicals called bases
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What are BASES?
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What are BASES?
  • Nitrogen- containing chemicals
  • The parts of the DNA molecule that join the two helix strands
  •  They are like rungs on a ladder


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What are BASES?
  • There are four bases: adenine (A), thymine (T), guanine (G) and cytosine (C)
  • Each base can only join with one other base
    • they join together in pairs: A with T and G with C.
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What are BASES?
  • The particular order of the bases is called the DNA sequence
  • The sequence gives the exact genetic instructions needed to create a particular organism with its own unique traits.